HCID 86615123, compound → HCID 86615122, compound

HRID 873556Notes

Reaction equation

HRID 873556 reaction equation
[C:1]([OH:8])(=O)[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]([N:26](C)[CH2:27][CH2:28][NH2:29])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O>N1CCCCC1.CN(C=O)C>[CH3:9][NH:26][CH2:27][CH2:28][NH:29][C:1](=[O:8])[CH2:2][CH2:3][C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 86615123HCID 86615123, compound

Product 1

HCID 86615122HCID 86615122, compound

Reagents, catalysts & solvents 1

HCID 23501187piperidine N,N-dimethylformamideSolvent2×

Procedure

The support bound N-(Fmoc)-N-methyl ethylenediamine succinate (105) was treated with 20% piperidine/DMF (10 mL—applied and then allowed to drain). An additional amount of 20% piperidine/DMF (10 mL) was then added and the slurry was agitated for 10 minutes. The support was then washed with DMF (10 mL×2), CH2Cl2 (10 mL×2) and finally with DMF (10 mL×2). The deprotected support (106) was then immediately used in Step 5.

Workup

  1. washThe support was then washed with DMF (10 mL×2), CH2Cl2 (10 mL×2) and finally with DMF (10 mL×2)

Sources & evidence

ORD record
ord-8bc7778ea1624563b353d7d03078a870
Source dataset
uspto-grants-2015_03
Patent number
US08975404B2

Reaction notes

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