HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873561Generated: October 30, 2026
Trifluoroacetic acid → N-(4-(piperidin-4-yloxy)phenyl)-1-(pyridin-3-yl)azetidine-3-carboxamide
https://huagongshe.com/reaction/873561
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(4-(1-(pyridin-3-yl)azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate | HCID 86702037 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-(piperidin-4-yloxy)phenyl)-1-(pyridin-3-yl)azetidine-3-carboxamide | HCID 86702038 | — |
Reaction Steps
tert-Butyl 4-(4-(1-(pyridin-3-yl)azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate (3.82 g, 8.44 mmol) was dissolved in 60 ml dichloromethane, cooled to 0° C. and treated with trifluoroacetic acid (10 ml). The mixture was allowed to warm to room temperature and was stirred for 2 hours. Removal of the solvent under vacuum provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08975398B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-7aba15ae0a2f4e70b2f8b2130dea4ece |
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| Source note | uspto-grants-2015_03 |
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