1-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid → HCID 86702041, compound

HRID 873565Notes

Reaction equation

HRID 873565 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:14][CH:13]([C:15]([OH:17])=O)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH:25]2[CH2:30][CH2:29][N:28]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:27][CH2:26]2)=[CH:21][CH:20]=1.N[C:39]1C=CC(OC2CCN(C(OC(C)(C)C)=O)CC2)=CC=1>>[CH2:1]([O:8][C:9]([N:11]1[CH2:39][CH2:12][C@H:13]([C:15]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([CH:25]3[CH2:26][CH2:27][N:28]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:29][CH2:30]3)=[CH:21][CH:20]=2)=[O:17])[CH2:14]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acidHCID 21940085tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylateHCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

Product 1

HCID 86702041HCID 86702041, compound

Procedure

The title compound was prepared as described in Example 1A, substituting (S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid and tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-198641265c074a5eb79118cd8e3a430c
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

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