HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,6-Dichloropyridazine → HCID 86702048, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,6-Dichloropyridazine | HCID 67331 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86702048 | HCID 86702048 | — |
Reaction Steps
tert-Butyl azetidin-3-ylcarbamate (500 mg, 2.90 mmol) and 3,6-dichloropyridazine (454 mg, 3.05 mmol) were combined in DMSO (5 mL) and N-ethyl-N-isopropylpropan-2-amine (563 mg, 4.35 mmol), and the mixture was heated overnight at 100° C. The mixture was cooled to room temperature and diluted with water. Filtration provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975398B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-3e33112adb46430a8732625ac441c45f |
| Source note | uspto-grants-2015_03 |