1-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid → HCID 86702110, compound

HRID 873575Notes

Reaction equation

HRID 873575 reaction equation
NC1C=CC(O[CH:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9]C2)=CC=1.[CH2:22]([N:26]1[CH:30]=[C:29]([C:31]2[S:35][C:34]([C:36]([OH:38])=O)=[CH:33][CH:32]=2)[CH:28]=[N:27]1)[CH:23]([CH3:25])[CH3:24].C(OC([N:49]1CC(C(O)=O)C1)=O)C1C=CC=CC=1>>[CH2:22]([N:26]1[CH:30]=[C:29]([C:31]2[S:35][C:34]([C:36]([NH:49][C@H:7]3[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[CH2:9]3)=[O:38])=[CH:33][CH:32]=2)[CH:28]=[N:27]1)[CH:23]([CH3:25])[CH3:24]

Participants

4

Reactant 3

HCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acidHCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylateHCID 86702052HCID 86702052, compound

Product 1

HCID 86702110HCID 86702110, compound

Procedure

The title compound was prepared as described in Example 1A, substituting (S)-tert-butyl 3-aminopyrrolidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate and 5-(1-isobutyl-1H-pyrazol-4-yl)thiophene-2-carboxylic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid.

Sources & evidence

ORD record
ord-245a4afcada94530b42f9bb7b141d2e1
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

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