1-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid → HCID 86702073, compound

HRID 873585Notes

Reaction equation

HRID 873585 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9]C2)=[CH:4][CH:3]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([N:28]2[CH2:32][CH2:31][C@H:30]([C:33](O)=[O:34])[CH2:29]2)[N:23]=1.C(OC(N1CC(C(O)=O)C1)=O)C1C=CC=CC=1>>[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([N:28]2[CH2:32][CH2:31][C@H:30]([C:33]([NH:1][C:2]3[CH:3]=[CH:4][C:5]([O:6][C@@H:7]4[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[CH2:9]4)=[CH:20][CH:21]=3)=[O:34])[CH2:29]2)[N:23]=1

Participants

4

Reactant 3

HCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acidHCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylateHCID 86702074HCID 86702074, compound

Product 1

HCID 86702073HCID 86702073, compound

Procedure

The title compound was prepared as described in Example 1A, substituting (R)-tert-butyl 3-(4-aminophenoxy)pyrrolidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate and (S)-1-(pyridazin-3-yl)pyrrolidine-3-carboxylic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid.

Sources & evidence

ORD record
ord-73c5d547118242e6bb59f3e25f220906
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

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