3,6-Dichloropyridazine → HCID 86702082, compound

HRID 873595Notes

Reaction equation

HRID 873595 reaction equation
[NH:1]1[CH2:4][CH:3]([C:5]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]3)=[CH:10][CH:9]=2)=[O:6])[CH2:2]1.[F:27][C:28]1[N:29]=[N:30][C:31](F)=[CH:32][CH:33]=1.ClC1N=NC(Cl)=CC=1>>[F:27][C:28]1[N:29]=[N:30][C:31]([N:1]2[CH2:4][CH:3]([C:5]([NH:7][C:8]3[CH:13]=[CH:12][C:11]([CH:14]4[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH2:19]4)=[CH:10][CH:9]=3)=[O:6])[CH2:2]2)=[CH:32][CH:33]=1

Participants

4

Reactant 3

HCID 673313,6-DichloropyridazineHCID 141761Pyridazine, 3,6-difluoro-HCID 86702043HCID 86702043, compound

Product 1

HCID 86702082HCID 86702082, compound

Procedure

The title compound was prepared as described in Example 147A, substituting tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate for tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate and 3,6-difluoropyridazine for 3,6-dichloropyridazine.

Sources & evidence

ORD record
ord-3839948986cb41ffa2d667e71deb3992
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

Loading…