2,2,2-trifluoro-N-[4-(pyridin-4-ylmethyl)phenyl]acetamide → 2,2,2-trifluoro-N-(4-(piperidin-4-ylmethyl)-phenyl]acetamide

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Reaction Steps

2,2,2-Trifluoro-N-(4-(pyridin-4-ylmethyl)phenyl)acetamide (28.5 g, 102 mmol) and acetic acid (205 ml) were added to platinum(IV) oxide (3.42 g, 15.06 mmol) in a 500 mL stainless steel pressure bottle and the mixture was stirred for 16 hours at 40 psi. The mixture was filtered through a nylon membrane and concentrated in vacuo; and the resulting residue was taken up in methanol (100 mL) and poured into diethyl ether (600 mL). The precipitate was filtered, washed with ether and dried with sodium sulfate to afford the title compound.

Provenance & Evidence