1-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid → HCID 86702123, compound

HRID 873608Notes

Reaction equation

HRID 873608 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5](OC2CCN(C(OC(C)(C)C)=O)CC2)=[CH:4][CH:3]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([N:28]2[CH2:31][CH:30]([C:32]([OH:34])=O)[CH2:29]2)[N:23]=1.[CH2:35]([O:42][C:43](N1CC(C(O)=O)C1)=[O:44])C1C=CC=CC=1>>[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([N:28]2[CH2:31][CH:30]([C:32]([NH:1][C:2]3[CH:3]=[CH:4][C:5]([C:43]([O:42][CH3:35])=[O:44])=[CH:20][CH:21]=3)=[O:34])[CH2:29]2)[N:23]=1

Participants

4

Reactant 3

HCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acidHCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylateHCID 86702124HCID 86702124, compound

Product 1

HCID 86702123HCID 86702123, compound

Procedure

The title compound was prepared as described in Example 1A, substituting methyl 4-aminobenzoate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate and 1-(pyridazin-3-yl)azetidine-3-carboxylic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid.

Sources & evidence

ORD record
ord-6d537c333a544b40ba3f14c093213459
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

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