4-Chloro-3-sulfamoylbenzoic acid → 3-(Aminosulfonyl)-4-chlorobenzoyl chloride

Participants

Reaction Steps

A mixture of 4-chloro-3-sulfamoyl-benzoic acid (50 g, 212 mmol) and thionyl chloride (31 mL, 424 mmol) are heated to reflux for 5 h then allowed to cool to room temperature. To this mixture is added hexane and the resulting solid is filtered, washed with hexane and dried in vacuo to yield 52.3 g (97%) of the title compound as an off-white solid.

Provenance & Evidence