反应详情

4-Methyl-3-sulfamoyl-benzoic acid (2 g, 10 mmol) is added to thionyl chloride (15 mL) and heated at reflux for 3 hours. Hexanes are added to the cooled solution and an oil forms. The hexanes are decanted and the oil is dissolved in methylene chloride and washed with hexanes. The solvent is removed under reduced pressure and the crude oil used in the next step.

1. temperatureheated
2. temperatureat reflux for 3 hours
3. customThe hexanes are decanted
4. dissolutionthe oil is dissolved in methylene chloride
5. washwashed with hexanes
6. customThe solvent is removed under reduced pressure