反应详情

A mixture of 0.5 g of 5-(9-acetyl-9H-carbazole-2-carbonyl)-2-chloro-benzenesulfonamide and 20 mL of potassium hydroxide solution (10% in water) is heated at reflux overnight and is allowed to cool to room temperature. The reaction mixture is extracted with ethyl acetate, washed with water then a saturated sodium chloride solution, and dried over sodium sulfate. After concentration the residue is loaded on Celite and purified by silica gel chromatography (1:1 hexanes/ethyl acetate) to give 5-(9H-carbazole-2-carbonyl)-2-chloro-benzenesulfonamide as dark orange crystals. MS (m/z): 385 (M+1).

1. temperatureis heated
2. temperatureat reflux overnight
3. extractionThe reaction mixture is extracted with ethyl acetate
4. washwashed with water
5. dry with materiala saturated sodium chloride solution, and dried over sodium sulfate
6. concentrationAfter concentration the residue
7. custompurified by silica gel chromatography (1:1 hexanes/ethyl acetate)