反应详情

Benzyl-indazole is dissolved in dimethylsulfoxide and potassium tert-butoxide (1 M solution in tetrahydrofuran) is added at room temperature. Oxygen is then bubbled into the solution for 5 minutes. The reaction is allowed to stir at room temperature for 18 h. The reaction is quenched with aqueous saturated ammonium chloride then extracted three times with ethyl acetate. The combined organic extracts are dried over sodium sulfate, and concentrated. Purification by flash chromatography provides the deprotected indazole.

1. customOxygen is then bubbled into the solution for 5 minutes
2. customThe reaction is quenched with aqueous saturated ammonium chloride
3. extractionthen extracted three times with ethyl acetate
4. dry with materialThe combined organic extracts are dried over sodium sulfate
5. concentrationconcentrated
6. customPurification by flash chromatography