Diisopropylethylamine → HCID 149434098, compound

Participants

Reaction Steps

(2E)-3-Mesitylacrylic acid (8.0 g; 42 mmol), diisopropylethylamine (27.2 g; 210 mmol), tert-butyl amino(imino)methylcarbamate (8.03 g; 50 mmol), and 1-hydroxybenzotriazole monohydrate (7.73 g; 50 mmol) were dissolved in N,N-dimethylformamide (170 mL), 2-(1H)-benzotriazol-1-yl-1,1,3,3-tetramethyluronium hexafluorophosphate (19.2 g; 50 mmol) was added thereto, and the mixture was stirred for 20 hours at room temperature. To the reaction solution, ethyl acetate (500 mL) was added, and the mixture was washed with 10% aqueous citric acid solution, brine, saturated aqueous sodium bicarbonate solution, and then brine. The organic layer was dried over anhydrous magnesium sulfate and then distilled under reduced pressure, to give 13.9 g of the title compound (yield 100%) as an oil.

Provenance & Evidence