Hydrochloric Acid → HCID 178425722, compound

Participants

Reaction Conditions

Reaction Steps

Iron powder (1.0 g) was suspended in 50% aqueous ethanol solution (100 mL), 12 mol/L hydrochloric acid (1.0 mL) was added thereto, and the mixture was stirred for 30 minutes at 70° C. To the mixture was added 2-(mesityloxy)-N-[4-(2-nitrophenyl)-1H-imidazol-2-yl]acetamide (Compound 18) (875 mg, 2.3 mmol) obtained in Example 18, and the mixture was stirred for 1 hour at 70° C. The mixture was left to cool, and then the insoluble materials were removed by filtration, and then the filtrate was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and then distilled under reduced pressure. The resulting residue was separated by silica gel column (0 to 3% methanol/chloroform), and the resulting crystals were dispersed in diethyl ether, collected by filtration and dried to give 520 mg of the title compound (yield 65%) expressed by the following formula (Ex. 19).

Provenance & Evidence