HCID 117702712, compound → HCID 86293725, compound

HRID 873798Notes

Reaction equation

HRID 873798 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:17]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:16]3[C:12](=[N:13][N:14](CC4C=CC(OC)=CC=4)[C:15]=3[CH3:25])[C:11]2=[O:35])[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:17]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:16]3[C:12](=[N:13][NH:14][C:15]=3[CH3:25])[C:11]2=[O:35])[CH:3]=1

Participants

3

Reactant 1

HCID 117702712HCID 117702712, compound

Product 1

HCID 86293725HCID 86293725, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 2 using 5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chlorophenyl)-2-(4-methoxybenzyl)-3-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one (Step 5.5). tR: 3.55 min (HPLC 1); tR: 0.78 min (LC-MS 2); ESI-MS: 389/391 [M+H]+ (LC-MS 2); Rf=0.34 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.03 (s, 3H) 3.43 (s, 3H) 6.13 (s, 1H) 7.25 (d, J=8.2 Hz, 2H) 7.36 (d, J=8.2 Hz, 2H) 7.90 (d, J=2.4 Hz, 1H) 7.94 (d, J=2.7 Hz, 1H) 13.38 (s, 1H).

Sources & evidence

ORD record
ord-58383dd31a7c41f6a7028e729768ba6d
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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