Morpholine → 1-Morpholin-4-yl-[2,6]naphthyridine

HRID 8738Notes

Reaction equation

HRID 8738 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][N:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][N:8]=[CH:9][CH:10]=3)[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 128847741-Chloro-2,6-naphthyridine

Product 1

HCID 219836751-Morpholin-4-yl-[2,6]naphthyridine

Procedure

To 1-chloro-2,6-naphthyridine (164.3 mg, 0.998 mmol) (prepared as described in Van den Haak et al, J. Org. Chem 1982, 47 (9), 1673–7) was added morpholine (15 mL) and the mixture was heated at reflux for 4 h. Removal of the volatile components gave 216.6 mg of 1-morpholin-4-yl-[2,6]naphthyridine as a beige solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 h
  3. customRemoval of the volatile components

Sources & evidence

ORD record
ord-617f60e42998408eb2d6587c55676ac9
Source dataset
uspto-grants-2006_08
Patent number
US07091200B2

Reaction notes

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