HCID 117702578, compound → HCID 178480577, compound

HRID 873802Notes

Reaction equation

HRID 873802 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:17]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:16]3[C:12](=[N:13][N:14](CC4C=CC(OC)=CC=4)[CH:15]=3)[C:11]2=[O:34])[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:17]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:16]3[C:12](=[N:13][NH:14][CH:15]=3)[C:11]2=[O:34])[CH:3]=1

Participants

3

Reactant 1

HCID 117702578HCID 117702578, compound

Product 1

HCID 178480577HCID 178480577, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 2 using 5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chlorophenyl)-2-(4-methoxybenzyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one (Step 9.6). tR: 3.39 min (HPLC 1); tR: 0.74 min (LC-MS 2); ESI-MS: 375/377 [M+H]+ (LC-MS 2); Rf=0.30 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 3.44 (s, 3H) 6.19 (s, 1H) 7.24 (d, J=8.6 Hz, 2H) 7.35 (d, J=8.6 Hz, 2H) 7.77-7.85 (m, 1H) 7.89-7.93 (m, 1H) 7.94-7.97 (m, 1H) 13.70 (br. s, 1H).

Sources & evidence

ORD record
ord-a968989b0b3646b5b10e35c703cff047
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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