HCID 117702958, compound → HCID 86293914, compound

HRID 873806Notes

Reaction equation

HRID 873806 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[C:12]2[C:13]([C:18](O)=[O:19])=[N:14][N:15]([CH3:17])[CH:16]=2)[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[C:12]3[C:13](=[N:14][N:15]([CH3:17])[CH:16]=3)[C:18]2=[O:19])[CH:3]=1

Participants

3

Reactant 1

HCID 117702958HCID 117702958, compound

Product 1

HCID 86293914HCID 86293914, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-ylamino)(4-chlorophenyl)methyl)-1-methyl-1H-pyrazole-3-carboxylic acid (Step 10.4). tR: 3.65 min (HPLC 1); tR: 0.82 min (LC-MS 2): ESI-MS: 389/391 [M+H]+ (LC-MS 2); Rf=0.56 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 3.45 (s, 3H) 3.98 (s, 3H) 6.21 (s, 1H) 7.26 (d, J=8.4 Hz, 2H) 7.38 (d, J=8.4 Hz, 2H) 7.79 (s, 1H) 7.90-8.04 (m, 2H).

Sources & evidence

ORD record
ord-c1571a18576f4a2f8b117882536c8b8b
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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