HCID 117703007, compound → HCID 86293916, compound

HRID 873809Notes

Reaction equation

HRID 873809 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:18][C:19]2[CH:24]=[C:23]([CH3:25])[C:22](=[O:26])[N:21]([CH3:27])[CH:20]=2)[C:9]2[C:10]([C:15](O)=[O:16])=[N:11][N:12]([CH3:14])[CH:13]=2)=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH3:14])[CH:13]=3)[C:15](=[O:16])[N:18]2[C:19]2[CH:24]=[C:23]([CH3:25])[C:22](=[O:26])[N:21]([CH3:27])[CH:20]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117703007HCID 117703007, compound

Product 1

HCID 86293916HCID 86293916, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-ylamino)methyl)-1-methyl-1H-pyrazole-3-carboxylic acid (Step 13.2). tR: 3.44 min (HPLC 1); tR: 0.77 min (LC-MS 2); ESI-MS: 369 [M+H]+ (LC-MS 2); Rf=0.46 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.92 (s, 3H) 3.37 (s, 3H) 3.95 (s, 3H) 6.15 (s, 1H) 7.22 (d, J=8.6 Hz, 2H) 7.38 (d, J=8.6 Hz, 2H) 7.40 (m, 1H) 7.81 (m, 1H) 7.86 (s, 1H).

Sources & evidence

ORD record
ord-114b58a18f5043fdbe67a3e2c6eb9cf7
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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