HCID 117702842, compound → HCID 86293917, compound

HRID 873811Notes

Reaction equation

HRID 873811 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:18][C:19]2[CH:24]=[C:23]([F:25])[C:22](=[O:26])[N:21]([CH3:27])[CH:20]=2)[C:9]2[C:10]([C:15](O)=[O:16])=[N:11][N:12]([CH3:14])[CH:13]=2)=[CH:4][CH:3]=1>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH3:14])[CH:13]=3)[C:15](=[O:16])[N:18]2[C:19]2[CH:24]=[C:23]([F:25])[C:22](=[O:26])[N:21]([CH3:27])[CH:20]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702842HCID 117702842, compound

Product 1

HCID 86293917HCID 86293917, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)(5-fluoro-1-methyl-6-oxo-1,6-dihydropyridin-3-ylamino)methyl)-1-methyl-1H-pyrazole-3-carboxylic acid (Step 14.4). Trituration in Et2O was done after purification on silica-gel. tR: 3.46 min (HPLC 1); tR: 0.76 min (LC-MS 2); ESI-MS: 373 [M+H]+ (LC-MS 2); Rf=0.44 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 3.46 (s, 3H) 3.98 (s, 3H) 6.21 (s, 1H) 7.26 (d, J=7.3 Hz, 2H) 7.38 (d, J=7.3 Hz, 2H) 7.66 (d, J=11.4 Hz, 1H) 7.76-7.87 (m, 2H).

Workup

  1. customafter purification on silica-gel

Sources & evidence

ORD record
ord-af83670540c04743a692b37cadf9eee5
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…