HCID 117702911, compound → HCID 86294096, compound

HRID 873814Notes

Reaction equation

HRID 873814 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:12]2[C:13]([C:21]([OH:23])=O)=[N:14][N:15]([CH:18]3[CH2:20][CH2:19]3)[C:16]=2[CH3:17])[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:24]3[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=3)[C:12]3[C:13](=[N:14][N:15]([CH:18]4[CH2:19][CH2:20]4)[C:16]=3[CH3:17])[C:21]2=[O:23])[CH:3]=1

Participants

3

Reactant 1

HCID 117702911HCID 117702911, compound

Product 1

HCID 86294096HCID 86294096, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-cyclopropyl-5-methyl-1H-pyrazole-3-carboxylic acid (Step 17.7). tR: 4.28 min (HPLC 1); tR: 0.96 min (LC-MS 2); ESI-MS: 429/431 [M+H]+ (LC-MS 2); Rf=0.56 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 0.96-1.19 (m, 4H) 2.14 (s, 3H) 3.43 (s, 3H) 3.57-3.68 (m, 1H) 6.13 (s, 1H) 7.27 (d, J=8.6 Hz, 2H) 7.36 (d, J=8.6 Hz, 2H) 7.89 (d, J=2.3 Hz, 1H) 7.92 (d, J=2.3 Hz, 1H).

Sources & evidence

ORD record
ord-971d96586ba24fdc81c2b6546da6e65e
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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