HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-3-chloro-1-methyl-1,2-dihydropyridin-2-one → ethyl 4-((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-ylamino)(4-chlorophenyl)methyl)-1-cyclopropyl-5-methyl-1H-pyrazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-3-chloro-1-methyl-1,2-dihydropyridin-2-one | HCID 71756073 | — |
| Reactant | ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-cyclopropyl-5-methyl-1H-pyrazole-3-carboxylate | HCID 117702986 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | ethyl 4-((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-ylamino)(4-chlorophenyl)methyl)-1-cyclopropyl-5-methyl-1H-pyrazole-3-carboxylate | HCID 117702777 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 10.3 using ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-cyclopropyl-5-methyl-1H-pyrazole-3-carboxylate (Step 17.5) and 5-amino-3-chloro-1-methylpyridin-2(1H)-one (Step 5.2). tR: 4.81 min (HPLC 1); tR: 1.09 min (LC-MS 2); ESI-MS: 475/477 [M+H]+ (LC-MS 2); Rf=0.52 (CH2Cl2/MeOH 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975417B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-715238e9b0654175b351172a3d656318 |
| Source note | uspto-grants-2015_03 |