HCID 117702593, compound → HCID 86294097, compound

HRID 873818Notes

Reaction equation

HRID 873818 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25](=[O:29])[N:24]([CH3:30])[CH:23]=2)[C:9]2[C:10]([C:18]([OH:20])=O)=[N:11][N:12]([CH:15]3[CH2:17][CH2:16]3)[C:13]=2[CH3:14])=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH:15]4[CH2:17][CH2:16]4)[C:13]=3[CH3:14])[C:18](=[O:20])[N:21]2[C:22]2[CH:27]=[C:26]([CH3:28])[C:25](=[O:29])[N:24]([CH3:30])[CH:23]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702593HCID 117702593, compound

Product 1

HCID 86294097HCID 86294097, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-cyclopropyl-5-methyl-1H-pyrazole-3-carboxylic acid (Step 20.4). tR: 4.06 min (HPLC 1); tR: 0.92 min (LC-MS 2); ESI-MS: 409.2 [M+H]+ (LC-MS 2); Rf=0.39 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 0.94-1.17 (m, 4H) 1.91 (s, 3H) 2.13 (s, 3H) 3.34 (s, 3H) 3.60-3.67 (m, 1H) 6.09 (s, 1H) 7.20-7.26 (m, 2H) 7.32-7.43 (m, 3H) 7.70 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-c46ad46c2e8a413fae1501412d588dd0
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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