HCID 117702797, compound → HCID 86294099, compound

HRID 873836Notes

Reaction equation

HRID 873836 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:19][C:20]2[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[N:22]([CH3:28])[CH:21]=2)[C:9]2[C:10]([C:16](O)=[O:17])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH3:15])[C:13]=3[CH3:14])[C:16](=[O:17])[N:19]2[C:20]2[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[N:22]([CH3:28])[CH:21]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 117702797HCID 117702797, compound

Product 1

HCID 86294099HCID 86294099, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-ylamino)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylic acid (Step 28.4). tR: 3.62 min (HPLC 1); tR: 0.81 min (LC-MS 2); ESI-MS: 383 [M+H]+ (LC-MS 2); Rf=0.55 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.92 (s, 3H) 2.05 (s, 3H) 3.35 (s, 3H) 3.83 (s, 3H) 6.10 (s, 1H) 7.24 (d, J=8.6 Hz, 2H) 7.33-7.41 (m, 3H) 7.72 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-c2fdce60976c4eedbbdf4983b3722ac7
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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