HCID 117702702, compound → HCID 86294277, compound

HRID 873838Notes

Reaction equation

HRID 873838 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:19][C:20]2[CH:25]=[C:24]([F:26])[C:23](=[O:27])[N:22]([CH3:28])[CH:21]=2)[C:9]2[C:10]([C:16](O)=[O:17])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH3:15])[C:13]=3[CH3:14])[C:16](=[O:17])[N:19]2[C:20]2[CH:25]=[C:24]([F:26])[C:23](=[O:27])[N:22]([CH3:28])[CH:21]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702702HCID 117702702, compound

Product 1

HCID 86294277HCID 86294277, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)(5-fluoro-1-methyl-6-oxo-1,6-dihydropyridin-3-ylamino)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylic acid (Step 31.2). tR: 3.64 min (HPLC 1); tR: 0.80 min (LC-MS 2); ESI-MS: 387 [M+H]+ (LC-MS 2); Rf=0.51 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.06 (s, 3H) 3.43 (s, 3H) 3.83 (s, 3H) 6.13 (s, 1H) 7.23-7.29 (m, 2H) 7.33-7.40 (m, 2H) 7.57-7.67 (m, 1H) 7.79 (br. s, 1H).

Sources & evidence

ORD record
ord-6a5cc440db054d1896f55db0e40d7a95
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…