HCID 117702779, compound → HCID 86294101, compound

HRID 873840Notes

Reaction equation

HRID 873840 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:19][C:20]2[CH:25]=[CH:24][C:23](=[O:26])[N:22]([CH3:27])[N:21]=2)[C:9]2[C:10]([C:16]([OH:18])=O)=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH3:15])[C:13]=3[CH3:14])[C:16](=[O:18])[N:19]2[C:20]2[CH:25]=[CH:24][C:23](=[O:26])[N:22]([CH3:27])[N:21]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 117702779HCID 117702779, compound

Product 1

HCID 86294101HCID 86294101, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)(1-methyl-6-oxo-1,6-dihydropyridazin-3-ylamino)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylic acid Step 32.3). tR: 3.94 min (HPLC 1); tR: 0.87 min (LC-MS 2); ESI-MS: 370 [M+H]+ (LC-MS 2); Rf=0.56 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.05 (s, 3H) 3.44 (s, 3H) 3.84 (s, 3H) 6.29 (s, 1H) 6.96 (d, J=9.8 Hz, 1H) 7.29-7.41 (m, 4H) 8.21 (d, J=9.8 Hz, 1H).

Sources & evidence

ORD record
ord-1d61027494a041e28035a7b11529dc5e
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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