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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873853Generated: October 26, 2026

1-Isopropylhydrazine hydrochloride → Ethyl 1-(1-methylethyl)-1H-pyrazole-5-carboxylate

https://huagongshe.com/reaction/873853

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Isopropylhydrazine hydrochlorideHCID 85573—
ReactantEthyl 4-(dimethylamino)-2-oxo-but-3-enoateHCID 2777802—
ProductEthyl 1-(1-methylethyl)-1H-pyrazole-5-carboxylateHCID 23005968—

Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 17.3 using isopropylhydrazine hydrochloride and ethyl 4-(dimethylamino)-2-oxobut-3-enoate at 120° C. for hr. The crude product was purified by silica gel column chromatography (hexane/EtOAc 2.5-40%). tR: 4.74 min (HPLC 1); tR: 1.00 min (LC-MS 2); ESI-MS: 183 [M+H]+ (LC-MS 2); Rf=0.95 (hexane/EtOAc 1:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975417B2
Source datasetuspto-grants-2015_03
ORD IDord-86d3d410267b472ebd8fb4e4ec51704d
Source noteuspto-grants-2015_03