反应详情

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid (Step 40.4) at RT for 30 min. tR: 1.12 min (LC-MS 2); ESI-MS: 483 [M+H]+ (LC-MS 2); Rf=0.69 (CH2Cl2/5% MeOH/1% ammonia); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.11-1.22 (m, 2H) 1.22-1.38 (m, 2H) 3.41 (s, 3H) 3.86-4.00 (m, 1H) 6.36 (s, 1H) 7.26 (m, J=8.6 Hz, 2H) 7.36 (m, J=8.6 Hz, 2H) 7.90 (d, J=2.7 Hz, 1H) 7.87 (d, J=2.7 Hz, 1H).