Ethyl 5,5,5-trifluoro-2,4-dioxopentanoate → ethyl 1-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

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Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 17.3 using cyclopropylhydrazine (Step 17.2) and ethyl 5,5,5-trifluoro-2,4-dioxopentanoate at 100° C. for 2 hr. The crude product was purified by silica gel column chromatography (Hexane/EtOAc 9:1). tR: 1.10 min (LC-MS 2); ESI-MS: 249 [M+H]+ (LC-MS 2); Rf=0.17 (hexane/EtOAc 9:1).

Provenance & Evidence