HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isopropylhydrazine hydrochloride → ethyl 1-isopropyl-1H-pyrazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isopropylhydrazine hydrochloride | HCID 85573 | — |
| Reactant | Ethyl 4-(dimethylamino)-2-oxo-but-3-enoate | HCID 2777802 | — |
| Product | ethyl 1-isopropyl-1H-pyrazole-3-carboxylate | HCID 23005998 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 17.3 using isopropylhydrazine hydrochloride and ethyl 4-(Dimethylamino)-2-oxobut-3-enoate at 120° C. for hr. The crude product was purified by silica gel column chromatography (hexane/EtOAc 2.5-40%). tR: 3.73 min (HPLC 1); tR: 0.80 min (LC-MS 2); ESI-MS: 183 [M+H]+ (LC-MS 2); Rf=0.69 (hexane/EtOAc 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975417B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-0397897ffa5048b4a847edc6a3cc9088 |
| Source note | uspto-grants-2015_03 |