HCID 117702988, compound → HCID 86294482, compound

HRID 873870Notes

Reaction equation

HRID 873870 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:12]2[C:13]([C:20](O)=[O:21])=[N:14][N:15]([CH:17]([CH3:19])[CH3:18])[CH:16]=2)[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)[C:12]3[C:13](=[N:14][N:15]([CH:17]([CH3:19])[CH3:18])[CH:16]=3)[C:20]2=[O:21])[CH:3]=1

Participants

3

Reactant 1

HCID 117702988HCID 117702988, compound

Product 1

HCID 86294482HCID 86294482, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid (Step 42.2). tR: 4.25 min (HPLC 1); tR: 0.95 min (LC-MS 2); ESI-MS: 417 [m+H]+(LC-MS 2); Rf=0.51 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.39-1.46 (m, 6H) 3.43 (s, 3H) 4.54-4.67 (m, 1H) 6.16 (s, 1H) 7.20-7.27 (m, 2H) 7.32-7.38 (m, 2H) 7.87 (s, 1H) 7.88-7.90 (m, 1H) 7.91-7.93 (m, 1H).

Sources & evidence

ORD record
ord-23e433ddf9064b7e81bcbc9d83fc4f35
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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