Ethyl 5,5,5-trifluoro-2,4-dioxopentanoate → ethyl 1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 17.3 using cyclopropylhydrazine (Step 17.2) and ethyl 5,5,5-trifluoro-2,4-dioxopentanoate at 100° C. for 2 hr. The crude product was purified by silica gel column chromatography (hexane/EtOAc 9:1). tR: 1.23 min (LC-MS 2); ESI-MS: 249.2 [M+H]+ (LC-MS 2); Rf=0.34 (hexane/EtOAc 9:1).

Provenance & Evidence