5-Amino-3-chloro-1-methyl-1,2-dihydropyridin-2-one → HCID 117702648, compound

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Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 40.3 using ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate (Step 47.2) and 5-amino-3-chloro-1-methylpyridin-2(1H)-one (Step 5.2). The crude product was purified by silica gel chromatography (50% EtOAc/CH2Cl2). tR: 1.21 min (LC-MS 2); ESI-MS: 627 [M+H]+ (LC-MS 2); Rf=0.20 (50% EtOAc/CH2Cl2).

Provenance & Evidence