HCID 117702825, compound → HCID 86291794, compound

HRID 873895Notes

Reaction equation

HRID 873895 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[C:12]2[C:13]([CH3:30])=[N:14][N:15]([C:20]3[C:21]([O:28][CH3:29])=[N:22][C:23]([O:26][CH3:27])=[N:24][CH:25]=3)[C:16]=2[C:17](O)=[O:18])[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=3)[C:12]3[C:13]([CH3:30])=[N:14][N:15]([C:20]4[C:21]([O:28][CH3:29])=[N:22][C:23]([O:26][CH3:27])=[N:24][CH:25]=4)[C:16]=3[C:17]2=[O:18])[CH:3]=1

Participants

3

Reactant 1

HCID 117702825HCID 117702825, compound

Product 1

HCID 86291794HCID 86291794, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-3-methyl-1H-pyrazole-5-carboxylic acid (Step 52.4). tR: 4.45 min (HPLC 1); tR: 1.02 min (LC-MS 2); ESI-MS: 527/529 [M+H]+ (LC-MS 2); Rf=0.41 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.99 (s, 3H) 3.41 (s, 3H) 3.93 (s, 3H) 3.96 (s, 3H) 6.21 (s, 1H) 7.30-7.36 (m, 2H) 7.38-7.44 (m, 2H) 7.87 (d, J=2.7 Hz, 1H) 7.92 (d, J=2.7 Hz, 1H) 8.56 (s, 1H).

Sources & evidence

ORD record
ord-6448a9f606904ebebf9e62ae1f433393
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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