HCID 117702717, compound → HCID 86291796, compound

HRID 873899Notes

Reaction equation

HRID 873899 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[C:12]2[C:13]([C:28](O)=[O:29])=[N:14][N:15]([C:18]3[C:19]([O:26][CH3:27])=[N:20][C:21]([O:24][CH3:25])=[N:22][CH:23]=3)[C:16]=2[CH3:17])[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=3)[C:12]3[C:13](=[N:14][N:15]([C:18]4[C:19]([O:26][CH3:27])=[N:20][C:21]([O:24][CH3:25])=[N:22][CH:23]=4)[C:16]=3[CH3:17])[C:28]2=[O:29])[CH:3]=1

Participants

3

Reactant 1

HCID 117702717HCID 117702717, compound

Product 1

HCID 86291796HCID 86291796, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-methyl-1H-pyrazole-3-carboxylic acid (Step 55.5). tR: 4.30 min (HPLC 1); tR: 0.98 min (LC-MS 2); ESI-MS: 527/529 [M+H]+ (LC-MS 2); Rf=0.37 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.91 (s, 3H) 3.44 (s, 3H) 3.92 (s, 3H) 3.96 (s, 3H) 6.24 (s, 1H) 7.29-7.42 (m, 4H) 7.93 (d, J=2.7 Hz, 1H) 7.97 (d, J=2.4 Hz, 1H) 8.53 (s, 1H).

Sources & evidence

ORD record
ord-0245bc56ed8d42b1af301fe0d7e57659
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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