HCID 117702892, compound → HCID 86291997, compound

HRID 873902Notes

Reaction equation

HRID 873902 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:28][C:29]2[CH:34]=[C:33]([CH3:35])[C:32](=[O:36])[N:31]([CH3:37])[CH:30]=2)[C:9]2[C:10]([C:25]([OH:27])=O)=[N:11][N:12]([C:15]3[C:16]([O:23][CH3:24])=[N:17][C:18]([O:21][CH3:22])=[N:19][CH:20]=3)[C:13]=2[CH3:14])=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([C:15]4[C:16]([O:23][CH3:24])=[N:17][C:18]([O:21][CH3:22])=[N:19][CH:20]=4)[C:13]=3[CH3:14])[C:25](=[O:27])[N:28]2[C:29]2[CH:34]=[C:33]([CH3:35])[C:32](=[O:36])[N:31]([CH3:37])[CH:30]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702892HCID 117702892, compound

Product 1

HCID 86291997HCID 86291997, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-methyl-1H-pyrazole-3-carboxylic acid (Step 56.2). tR: 4.10 min (HPLC 1); tR: 0.94 min (LC-MS 2); ESI-MS: 507 [M+H]+ (LC-MS 2); Rf=0.44 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.88-1.95 (m, 6H) 3.35 (s, 3H) 3.92 (s, 3H) 3.96 (s, 3H) 6.21 (s, 1H) 7.26-7.33 (m, 2H) 7.35-7.44 (m, 3H) 7.75 (d, J=2.7 Hz, 1H) 8.53 (d, J=0.8 Hz, 1H).

Sources & evidence

ORD record
ord-68c7bd0056e64596b8d2fe6a133b5c7c
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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