Ethyl acetate hexane → ethyl 1-(2-methoxypyrimidin-4-yl)-3-methyl-1H-pyrazole-5-carboxylate

HRID 873909Notes

Reaction equation

HRID 873909 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([O:9][CH3:10])[N:4]=1)[NH2:2].[CH3:11][CH2:12][CH2:13]CCC.[CH3:17][CH2:18][O:19][C:20]([CH3:22])=[O:21]>>[CH3:10][O:9][C:5]1[N:4]=[C:3]([N:1]2[C:22]([C:20]([O:19][CH2:18][CH3:17])=[O:21])=[CH:11][C:12]([CH3:13])=[N:2]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 1177027404-Hydrazinyl-2-methoxypyrimidine

Product 1

HCID 117702875ethyl 1-(2-methoxypyrimidin-4-yl)-3-methyl-1H-pyrazole-5-carboxylate

Procedure

The title product was prepared in analogy to the procedure described in Example 57 using 4-hydrazinyl-2-methoxypyrimidine (Step 59.1). tR: 4.28 min (HPLC 1); tR: 0.93 min (LC-MS 2); ESI-MS: 263 [M+H]+ (LC-MS 2); Rf=0.58 (hexane/EtOAc 1:1).

Sources & evidence

ORD record
ord-956896c628ca43a79a9540ec37483e1d
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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