5-Amino-1,3-dimethyl-1,2-dihydropyridin-2-one → HCID 117702725, compound

HRID 873911Notes

Reaction equation

HRID 873911 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[C:9]2[C:10]([CH3:27])=[N:11][N:12]([C:19]3[CH:24]=[CH:23][N:22]=[C:21]([O:25][CH3:26])[N:20]=3)[C:13]=2[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:4][CH:3]=1.[NH2:29][C:30]1[CH:31]=[C:32]([CH3:38])[C:33](=[O:37])[N:34]([CH3:36])[CH:35]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:29][C:30]2[CH:31]=[C:32]([CH3:38])[C:33](=[O:37])[N:34]([CH3:36])[CH:35]=2)[C:9]2[C:10]([CH3:27])=[N:11][N:12]([C:19]3[CH:24]=[CH:23][N:22]=[C:21]([O:25][CH3:26])[N:20]=3)[C:13]=2[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 674566165-Amino-1,3-dimethyl-1,2-dihydropyridin-2-oneHCID 117702898HCID 117702898, compound

Product 1

HCID 117702725HCID 117702725, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 10.3 using ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-(2-methoxypyrimidin-4-yl)-3-methyl-1H-pyrazole-5-carboxylate (Step 59.4) and 5-amino-1,3-dimethylpyridin-2(1H)-one (Step 20.2). tR: 4.90 min (HPLC 1); tR: 1.15 min (LC-MS 2); ESI-MS: 523 [M+H]+ (LC-MS 2); Rf=0.47 (CH2Cl2/MeOH 9:1).

Sources & evidence

ORD record
ord-40003c29b09c4c5f8a49f740d8ce0f97
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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