1-Isopropylhydrazine hydrochloride → 5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chlorophenyl)-1-isopropyl-3-methyl-4,5-dihydropyrrolo-[3,4-c]pyrazol-6(1H)-one

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described in Example 58 using 5-(3-acetyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-chloro-1-methyl-pyridin-2(1H)-one (Step 58.1) and isopropylhydrazine hydrochloride. tR: 4.69 min (HPLC 1); tR: 1.09 min (LC-MS 2); ESI-MS: 431/433 [M+H]+ (LC-MS 2); Rf=0.55 (EtOAc); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.45-1.57 (m, 6H) 1.93 (s, 3H) 3.44 (s, 3H) 4.67-4.79 (m, 1H) 6.11 (s, 1H) 7.28 (d, J=8.2 Hz, 2H) 7.40 (d, J=8.2 Hz, 2H) 7.91 (d, J=2.0 Hz, 1H) 7.95 (d, J=2.4 Hz, 1H).

Provenance & Evidence