HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → 4-acetyl-5-(4-chlorophenyl)-3-hydroxy-1-[(4-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Ethyl 2,4-dioxovalerate | HCID 69208 | — |
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Product | 4-acetyl-5-(4-chlorophenyl)-3-hydroxy-1-[(4-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrol-2-one | HCID 117702896 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 57.1 using 4-methoxybenzylamine, 4-chlorobenzaldehyde and ethyl 2,4-dioxovalerate at 120° C. for 3 hr. The title product precipitated at RT. tR: 4.90 min (HPLC 1); tR: 1.03 min (LC-MS 2); ESI-MS: 372 [M+H]+, ESI-MS: 370 [M−H]− (LC-MS 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975417B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-1ba38a5ec68244cea8971ebda594022b |
| Source note | uspto-grants-2015_03 |