Ammonia → HCID 86292587, compound

HRID 873933Notes

Reaction equation

HRID 873933 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:15]3[C:11](=[N:12][N:13]([CH3:17])[C:14]=3[OH:16])[C:10](=[O:18])[N:9]2[C:19]2[CH:24]=[C:23]([CH3:25])[C:22](=[O:26])[N:21]([CH3:27])[CH:20]=2)=[CH:4][CH:3]=1.[CH3:28]I.N>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:15]3[C:11](=[N:12][N:13]([CH3:17])[C:14]=3[O:16][CH3:28])[C:10](=[O:18])[N:9]2[C:19]2[CH:24]=[C:23]([CH3:25])[C:22](=[O:26])[N:21]([CH3:27])[CH:20]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6328Methyl iodideHCID 178428083HCID 178428083, compound

Product 1

HCID 86292587HCID 86292587, compound

Procedure

The title compound was prepared in analogy to the procedure described in Example 76 using 4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-hydroxy-2-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one (Example 73) and methyl iodide. tR: 0.86 min (LC-MS 2); ESI-MS: 399 [M+H]+ (LC-MS 2); Rf=0.33 (1% ammonia/7.5% MeOH/CH2Cl2); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.91 (s, 3H) 3.34 (s, 3H) 3.59 (s, 3H) 3.67 (s, 3H) 6.24 (s, 1H) 7.19-7.42 (m, 5H) 7.64 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-fbf9cb9569ce4914975a477450cfedaf
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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