4-(Trifluoromethyl)benzaldehyde → HCID 117702734, compound

HRID 873956Notes

Reaction equation

HRID 873956 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[F:11][C:12]([F:22])([F:21])[C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1.CC[O:25][C:26]([C:28]([CH2:30][C:31]([CH3:33])=[O:32])=[O:29])=O>>[C:31]([CH:30]1[CH:17]([C:16]2[CH:19]=[CH:20][C:13]([C:12]([F:22])([F:21])[F:11])=[CH:14][CH:15]=2)[N:1]([C:2]2[CH:3]=[C:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=2)[C:26](=[O:25])[C:28]1=[O:29])(=[O:32])[CH3:33]

Participants

4

Reactant 3

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 69208Ethyl 2,4-dioxovalerateHCID 674566165-Amino-1,3-dimethyl-1,2-dihydropyridin-2-one

Product 1

HCID 117702734HCID 117702734, compound

Procedure

The title compound was prepared in analogy to the procedure described in Step 57.1 using 5-amino-1,3-dimethylpyridin-2(1H)-one (Step 20.2), 4-trifluormethylbenzaldehyde and ethyl acetopyruvate. tR: 0.76 min (LC-MS 2); ESI-MS: 407 [M+H]+ (LC-MS 2); ESI-MS: 405 [M−H]− (LC-MS 2).

Sources & evidence

ORD record
ord-c9f35a2db0094408aff4ecd43f9bf961
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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