HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-methyl-3-nitropyridin-2-amine → 6-Chloro-N2-methylpyridine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-methyl-3-nitropyridin-2-amine | HCID 10750094 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 6-Chloro-N2-methylpyridine-2,3-diamine | HCID 24903942 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 85.2 using 6-chloro-N-methyl-3-nitropyridin-2-amine (Step 102.1) at RT for 23 hr. The crude material was purified by silica gel column chromatography (25% EtOAc/hexane) to afford a purple solid. tR: 0.64 min (LC-MS 2); ESI-MS: 158 [M+H]+ (LC-MS 2); Rf=0.12 (25% EtOAc/Hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975417B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-0a879d7077ac48089d4d9bc2038bb039 |
| Source note | uspto-grants-2015_03 |