4-Methyloxybenzyl chloride → Tert-butyl (6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)(4-methoxybenzyl)-carbamate

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 112.5 using tert-butyl (6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate (Step 112.4) and 4-methoxybenzylchloride at 80° C. for 1 hr. The crude product was purified by silica gel column chromatography (hexane/EtOAc 10-25%). tR: 5.35 min (HPLC 1); tR: 1.19 min (LC-MS 2); ESI-MS: 404 [M+H]+ (LC-MS 2); Rf=0.74 (hexane/EtOAc 1:1) Step 126.2: tert-butyl (6-(4-(4-chlorophenyl)-1-cyclopropyl-3-methyl-6-oxopyrrolo[3,4-c]pyrazol-5

Provenance & Evidence