Dichloromethane methanol → HCID 91826341, compound

HRID 874000Notes

Reaction equation

[NH:1]1[CH2:4][CH:3]([N:5]2[C:9]3[C:10](=[O:29])[N:11]([C:20]4[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[N:22]([CH3:28])[CH:21]=4)[CH:12]([C:13]4[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=4)[C:8]=3[C:7]([CH3:30])=[N:6]2)[CH2:2]1.[CH2:31](Cl)Cl.CO>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([CH:12]2[C:8]3[C:7]([CH3:30])=[N:6][N:5]([CH:3]4[CH2:2][N:1]([CH3:31])[CH2:4]4)[C:9]=3[C:10](=[O:29])[N:11]2[C:20]2[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[N:22]([CH3:28])[CH:21]=2)=[CH:14][CH:15]=1

Participants

Reactant 2

HCID 21226129Dichloromethane methanol

HCID 91826339HCID 91826339, compound

Product 1

HCID 91826341HCID 91826341, compound

Procedure

The title compound was prepared using an analogous procedure to that described in Step 139.2 using 1-(azetidin-3-yl)-4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (Step 138.2). tR: 0.61 min (LC-MS 2); ESI-MS: 438.1 [M+H]+ (LC-MS 2); Rf=0.29 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.83-1.96 (m, 6H) 2.33 (s, 3H) 3.35 (s, 3H) 3.45-3.59 (m, 2H) 3.66-3.78 (m, 2H) 4.97-5.10 (m, 1H) 6.07 (s, 1H) 7.26 (d, J=8.60 Hz, 2H) 7.33-7.42 (m, 3H) 7.71 (d, J=2.74 Hz, 1H).

Sources & evidence

ORD record: ord-cf5ce97c37564842ad9dd4bbe1cc0f3b
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08975417B2

Reaction notes

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