Dimethylcarbamoyl Chloride → HCID 91826342, compound

Participants

Reaction Steps

A mixture of 4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (Example 27) (200 mg, 0.542 mmol) and dimethylcarbamic chloride (0.06 mL, 0.651 mmol) in pyridine (2 mL) for 8 h at 100° C. The reaction mixture was concentrated, diluted in CH2Cl2/water, and extracted twice with CH2Cl2. The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated. The residue was purified by chromatography (1% ammonia/5% MeOH/CH2Cl2), subsequent preparative achiral SFC (column: Reprosil 70 NH2, 250×30 mm, 5 μm, Dr Maisch; eluent: MeOH/scCO2; gradient: 1 min 15% MeOH, 15-20% MeOH in 6 min, 20-50% MeOH in 1 min, 1.5 min 50% MeOH; flow: 100 mL/min) and trituration of the resulting products in diethyl ether to afford 68 mg of 4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-N,N,3-trimethyl-6-oxo-5,6-dihydropyrrolo[3,4-c]pyrazole-1(4H)-carboxamide (Example 142) and 62 mg of the title compound. tR: 0.85 min (LC-MS 2); ESI-MS: 440.1 [M+H]+ (LC-MS 2); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.95 (s, 3H) 2.15 (s, 3H) 2.95 (s, 3H) 3.08 (s, 3H) 3.38 (s, 3H) 6.22 (s, 1H) 7.33 (d, J=8.42 Hz, 2H) 7.37-7.48 (m, 3H) 7.79 (d, J=2.64 Hz, 1H).

Provenance & Evidence