Dimethyl 2,2'-(ethane-1,2-diyldisulfanediyl)diacetate → (Ethylenedithio)diacetic Acid

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Reaction Steps

Dimethyl 2,2′-(ethane-1,2-diylbis(sulfanediyl))diacetate (7.00 g, 29.4 mmol) was heated to reflux for two hours in 2 N HCl (50 mL). Cooling the mixture to room temperature gave a clear solution, which was concentrated to dryness in vacuo, giving Compound 3 as a white solid, 5.98 g (96.8%). 1H NMR (400 MHz, D2O) δ 3.47 (s, 4H), 2.95 (s, 4H). 13C NMR (101 MHz, D2O) δ 174.61, 33.28, 31.39.

Provenance & Evidence