Ethanol → Retinol

HRID 874068Notes

Reaction equation

HRID 874068 reaction equation
C(OCCOC(=O)C(C)=C)(=O)C(C)=C.C(O)C.[CH3:18][C:19]1[CH2:24][CH2:23][CH2:22][C:21]([CH3:26])([CH3:25])[C:20]=1/[CH:27]=[CH:28]/[C:29](/[CH3:38])=[CH:30]/[CH:31]=[CH:32]/[C:33](/[CH3:37])=[CH:34]/[CH:35]=[O:36]>O>[CH3:18][C:19]1[CH2:24][CH2:23][CH2:22][C:21]([CH3:25])([CH3:26])[C:20]=1/[CH:27]=[CH:28]/[C:29](/[CH3:38])=[CH:30]/[CH:31]=[CH:32]/[C:33](/[CH3:37])=[CH:34]/[CH2:35][OH:36]

Participants

5

Reactant 3

HCID 702EthanolHCID 7355Ethylene glycol dimethacrylateHCID 638015Retinal

Product 1

HCID 445354RetinolYield 96.78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

50 g of mesoporous polymer beads having a size of 10 nm and made of polymethylmethacrylate crosslinked with ethyleneglycol dimethacrylate was added to ethanol in a 5 L beaker, was stirred for 40 minutes or more using an agi mixer, was mixed with 2 g of butylated hydroxytoluene, and was then dissolved to prepare a first mixed solution. Subsequently, 40 g of retinal (vitamin A) was added to the first mixed solution, was completely dissolved, was mixed with purified water, and was then stirred for 5 minutes or more to prepare a second mixed solution. Subsequently, the second mixed solution was filtered under reduced pressure to obtain retinol-adsorbed mesoporous polymer beads, and then the retinol-adsorbed mesoporous polymer beads were vacuum-dried at 45° C. (yield: 96.78%).

Workup

  1. dissolutionwas then dissolved
  2. customto prepare a first mixed solution
  3. dissolutionwas completely dissolved
  4. stirringwas then stirred for 5 minutes or more
  5. customto prepare a second mixed solution
  6. filtrationSubsequently, the second mixed solution was filtered under reduced pressure

Sources & evidence

ORD record
ord-1d82ef18a7f341e8a91223e4ec0b6be2
Source dataset
uspto-grants-2015_03
Patent number
US08980293B2

Reaction notes

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