(S)-3-(5-(1-methylpyrrolidin-2-yl)pyridin-3-yl)propanenitrile → (S)-3-(5-(1-methylpyrrolidin-2-yl)pyridin-3-yl)propan-1-amine

Participants

Reaction Steps

(S)-3-(5-(1-Methylpyrrolidin-2-yl)pyridin-3-yl)propanenitrile (preparation 3) (140 mg, 0.65 mmol) and Raney nickel (50 mg) in 20% ammonia in MeOH (50 mL) were stirred under 50 psi hydrogen at 50° C. for 4 hours. The reaction mixture was filtered through Celite then the solvent evaporated. The crude product was purified by flash chromatography (7% [20% ammonia in MeOH] in DCM) to give the title compound as a pale yellow oil (126 mg, 88%).

Provenance & Evidence